Ohio &
Mississippi River

Soul-stirring river views and Midwest warmth welcome those who pursue relaxation. Mysteries of the past enlist life-long learners while sprawling parks and trails make way for recreation. Discover hidden American gems best reached by riverway. Lovers of adventure, connoisseurs of culture, and devotees of cuisine — welcome to the Mississippi and Ohio rivers.

Louisville, KY

high stakes

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Madison, Indiana

This charismatic port flaunts its personality throughout the streets, where a 133-block historic district showcases its collection of classic architectural artistry. Admire the antique machinery at the Schroeder House, or an example of fine craftsmanship at the Lanier Mansion State Historic Site. The downtown shopping district is a unique showcase of unbeatable hospitality, with each shop locally owned and operated.

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Cincinnati, Ohio

This jewel on the Ohio has a colorful character and intrinsic charm. In Cincinnati, each district has its own personality, which you can appreciate because the compact downtown is anchored to the river. As the riverfront continues its facelift, it seems Cincinnati’s next chapter will be just as successful as its past.

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Pittsburgh, PA

Where the prince of pop art is a native son
and the home team is made of steel.

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Ohio River Cruises

Experience one of America’s greatest rivers and enjoy the idyllic countryside and warm hospitality of the Ohio River onboard a unique riverboat. It’s a scenic voyage that lands you in small-town America, each with its own charms and museums that highlight its past.  


Discover the key role the Ohio river played in the development of the American West and unveil a new element with each port of call. As you cruise the river, you can expect to learn about the history of the surrounding area involving the Civil War. And with 12 itineraries to choose from, American Queen Voyages’ Ohio River cruises offer a vast array of cultural diversity that will captivate your heart.  


Ohio River Cruise FAQs 

What are the best ports to visit on an Ohio River cruise? 

The Ohio river is nearly 1000 miles long and stretches from Pittsburg, Pennsylvania, all the way to the mighty Mississippi river. Ohio River cruises with American Queen Voyages visit destinations such as Cincinnati, Ohio, Madison, Indiana, Louisville and Paducah, Kentucky, St. Louis, Missouri, Memphis and Nashville, Tennessee, and so much more.  


How long are Ohio River cruises?  

Ohio River cruises with American Queen Voyages last nine spectacular days and include six to eight port visitations depending on your itinerary of choice. However, you can combine your Ohio River cruise with a Mississippi river (link) voyage for a wholesome American heartland experience. 


What is included in an Ohio River Cruise? 

Ohio River cruises with American Queen Voyages include high-quality amenities and luxurious and spacious staterooms to ensure you feel at home away from home. Included in the cost of the cruise you will be welcomed with a one-night pre-cruise hotel stay, ground transfers between hotel and vessel, personally tailored and expertly crafted unlimited guided tours, unlimited beverages at open bars and lounges, acclaimed cuisine in multiple venues, in-room dining, unlimited Wi-Fi, live entertainment and enrichment onboard, and bicycles and hiking sticks. Airfare is not included in the price of the cruise and should be organized by guests separately. 


Are there Ohio River cruises that leave from Cincinnati?  

American Queen Voyages offer two fascinating Ohio River cruises that depart from Cincinnati. Cincinnati to Nashville is a nine-day cruise taking guests through 8 ports, including quaint river towns like Madison, Indiana, quirky and diverse Louisville, Kentucky, scenic and historic Brandenburg, Paducah, Kentucky, and more. The roundtrip Cincinnati cruise is a nine-day and five-port voyage that starts and ends in Cincinnati. The cruise passes through charming towns and vibrant cities, like Louisville, Kentucky, Madison, Indiana, Brandenburg, and Augusta, Kentucky. 


What sights can you see along the Ohio River? 

  • One of the key destinations along the Ohio River is Cincinnati, Ohio. You will never get to see it as you will onboard an Ohio River cruise with American Queen Voyages. The panoramic views will unfold before you as you glide past the landmarks, observe them from the vantage point of your riverboat, and then visit National Historic Sites and museums.  
  • Sailing through Louisville, Kentucky, the home of the Kentucky Derby, you get to discover horse racing and sample whiskey at a local distillery.  
  • Explore the music scene in Memphis, Tennessee. Visit the house of Elvis Presley, learn about the country’s troubled history at the National Civil Rights Museum, and taste the city’s famous barbecue dishes.  
  • In Madison, Indiana, discover the largest contiguous National Historic Landmark in the US, constructed of 133 blocks. 
  • Marvel at the architectural sensation “The Gateway Arch” in St. Louis, Missouri, which is almost twice as tall as the Statue of Liberty. And wander around the Missouri Botanical Gardens, a National Historic Landmark and one of the oldest botanical gardens in the US.
  • The Ohio River cruises include these highlights and so much more. Pick the perfect voyage for you among the 12 itineraries that American Queen Voyages offer.