Lower —

Follow the currents of the Mississippi Delta that have inspired storytellers and creators for centuries, where strains of Memphis blues and New Orleans jazz fill the air and the flavors of Southern cooking comfort the soul. Visit the hallowed grounds of Civil War battlefields in Vicksburg and the South’s largest existing historic mansion during an exclusive call to Nottoway.

New Orleans, LA

hot crawfish fiestas and

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Baton Rouge, Louisiana

Baton Rouge is strikingly different from the small-town stops along your voyage. In this energetic port, history-facing museums and landmarks fraternize with forward- looking art and industry. Explore the diversity this city has to offer on one of our deluxe motorcoach tours or take a walk down the river.

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Natchez, Mississippi

This charming river town, founded in 1716, is known for its elegance, Southern hospitality, and preservation of history – found on every street corner. Enjoy the unique shops, restaurants, museums, and historic homes, all of which inspired Hugh Bayless to include Natchez in his book “The 100 Best Towns in America.”

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Memphis, TN

With bluegrass banjos and Memphis soul.

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Lower Mississippi River

Join American Queen Voyages aboard a Lower Mississippi River voyage, America’s most iconic river boat adventure. Winding from St. Louis, Missouri, to New Orleans, Louisiana, adventures, culture, and history are packed into every bend of the river. The voyage will take you through picturesque port stops like Nottoway, Baton Rouge, Natchez, Vicksburg, and New Orleans. You can pick from four incredible itineraries lasting from 8 to 9 days and watch the striking scenery change with each destination, all from the comfort of your luxurious river boat.


Explore Civil War battlegrounds, indulge in Southern cooking, and enjoy the sounds of New Orleans’s jazz on your once-in-a-lifetime Mississippi River cruise. Join an immersive excursion in every port tailor-made for you and return onboard the iconic paddle-wheeler to sophisticated entertainment and fine dining. Adventures through America’s heartland await.


Mississippi River Cruise FAQs

What is the best time to go on a Mississippi River cruise?
The best time of the year to embark on your Mississippi cruise is in spring or fall. During these seasons, you avoid the summer heat and the winter chill and enjoy more pleasant weather as you explore every port.


Where do Mississippi River cruises start and end?
Because of its vastness, the river is divided into Lower Mississippi River cruises, Upper Mississippi River cruises, and Ohio & Mississippi River cruises. When sailing the Lower Mississippi River, the adventure starts or ends in Memphis, New Orleans, or St. Louis. You can choose your ideal itinerary from our variety of voyages.


How long is a Mississippi River cruise?
The cruises last from eight to nine days, but if you want to conquer more of the Mississippi River, you have the option to embark on another cruise back-to-back.


What are some of the most popular ports to visit along the Mississippi River when cruising?
New Orleans, Louisiana
Wander around the beautiful French Quarter neighborhood, taste Southern and Creole cooking and listen to world-renowned jazz music.

Vicksburg, Mississippi
Visit the site of the Civil War battlefield, discover the heritage of historical plantations, and learn how Vicksburg’s ancestors used to live along the river.

Baton Rouge, Louisiana
Explore Louisiana’s state capital and uncover its intriguing mix of cultures and cuisine. Home to numerous festivals throughout the year, Baton Rouge has much for travelers to discover.

Memphis, Tennessee
Visit the city’s biggest tourist attraction – Elvis’ home. Embrace the diversity of Memphis and learn its incredible history at The National Civil Rights Museum.

St. Louis, Missouri
Marvel at the iconic Gateway Arch and take in the panoramic views it offers over St. Louis and the mighty Mississippi. Sit back and relax at the Missouri Botanical Garden, where the aroma of flowers greets you with open arms.


Do Mississippi River cruises include airfare?
Airfare is not included in our Mississippi River cruises. Our voyages include an all-inclusive experience with a one-night pre-cruise hotel stay, ground transfers between hotel & vessel, unlimited guided tours, regionally inspired cuisine, unlimited wines, beers, and spirits, Wi-Fi, and live daily onboard entertainment and enrichment.


What to wear on a Mississippi River cruise?
During the day, river cruisers dress casually with comfort in mind. Bring items to explore the ports and pack layers just in case the weather takes a turn. At dinner, most cruisers opt for country club casual attire.


What sets American Queen Voyages apart from other cruise lines that do Mississippi River cruises?
Embarking on a Mississippi River cruise with American Queen Voyages is the adventure of a lifetime with all-inclusive value. It’s a one-of-a-kind cruise on the most iconic and authentic riverboats. Each voyage includes timeless luxury, five-star hospitality, fine dining that highlights local flavors, and unforgettable experiences tailor-made for you. The intimacy of small ship cruising allows our gracious crew to provide personalized service to each guest.


More Popular Mississippi River Cruises 

Upper Mississippi & Illinois River Cruises | Minneapolis to St. Louis Cruises | St. Louis to Minneapolis Cruises | Minneapolis to New Orleans Cruises | New Orleans to Memphis Cruises | Memphis to St. Louis Cruises | Roundtrip New Orleans Cruises | St. Louis to Memphis Cruises | Chicago to St. Louis Cruises | St. Louis to Ottawa Cruises